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뉴스래터 2019vol. 4

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2019-05-31 11:25
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Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study


Hounyoung Kim, Ji Eun Shin, Hwa Seon Koo, Hwang Kwon, Dong Hee Choi and Ji Hyang Kim


Department of Obstetrics and Gynecology, Fertility Center of CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea



  • Objective : Thin or damaged endometrium remains to be an unsolved problem in the treatment of patients with infertility. The empirical preference for endometrial thickness (EMT) among clinicians is >7mm, and the refractory thin endometrium, which doesn’t respond to standard medical therapies, can be the etiology of recurrent implantation failure (RIF). Autologous platelet-rich plasma (PRP) is known to help tissue regeneration and is widely used in various fields. In the present study, we conducted PRP treatment and investigated its effect on the refractory thin endometrium.

  • Results : The ongoing pregnancy rate and LBR were both 20%. The implantation and clinical pregnancy rates were 12.7 and 30%, respectively, and the difference was statistically significant. The average increase in the EMT was 0.6mm compared with the EMT of their previous cycle. However, this difference was not tatistically significant. Further, EMT of 12 patients increased (mean difference: 1.3mm), while that of seven patients decreased (mean difference: 0.7mm); the EMT of one patient did not change. There were no adverse effects reported by the patients who were treated with autologous PRP.


Source : https://www.frontiersin.org/articles/10.3389/fendo.2019.00061/full

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